2,6-Dichloromescaline
2,6-Dichloromescaline (2,6-CM) is a psychedelic drug in the mescaline family. It is the 2,6-dichloro version of mescaline and is also called dichloromescaline (DCL-M) or 2,6-dichloro-3,4,5-trimethoxyphenethylamine.
What it is
- A designer psychedelic related to mescaline.
- Not a medical drug and has appeared in the designer-drug scene since at least the 1990s.
How it acts
- It binds to serotonin receptors in the brain, especially 5-HT2A, as well as 5-HT1A and 5-HT2C.
- It tends to have higher receptor affinity than mescaline (example Ki values: 5-HT1A ~86 nM, 5-HT2A ~659 nM, 5-HT2C ~801 nM).
Chemical details (simplified)
- Chemical name: 2-(2,6-dichloro-3,4,5-trimethoxyphenyl)ethan-1-amine
- Formula: C11H15Cl2NO3
- Approximate molar mass: 280.15 g/mol
- Other names: 2,6-CM; DCL-M; 2,6-dichloro-3,4,5-trimethoxyphenethylamine
History
- First described in scientific literature in 1977.
- Receptor-affinity information published by researchers in 2013.
Legal status
- Not a controlled substance in Canada as of 2025.
This page was last edited on 2 February 2026, at 14:42 (CET).