Β-LGND2

Content sourced from Wikipedia, licensed under CC BY-SA 3.0.

β-LGND2, also known as ERβ-selective ligand 2 or GTx-878, is a synthetic, nonsteroidal estrogen that acts as a selective agonist for estrogen receptor beta (ERβ). It was developed by GTx for potential use in treating benign prostatic hyperplasia, prostatitis, and rheumatoid arthritis, but it never reached the market. The compound is about 25-fold more selective for ERβ than for ERα, with an EC50 of roughly 2 nM for ERβ and about 52 nM for ERα. β-LGND2 is an isoquinolinone derivative.